Catalog No. SBB-SC0118-50, 25-50 µg
SKP1 (S-phase kinase-associated protein 1) is an essential component of SCF (SKP1-CUL1-F-box protein) E3 Ubiquitin ligases that mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 is the adapter protein that links Cullin-1 to various F-box proteins (such as SKP2) that serve as the substrate recognition components of SCF ligases. SKP2 targets include proteins involved in cell cycle progression and signal transduction.
Skp1/His6-Skp2
SKP1 (S-phase kinase-associated protein 1) is an essential component of SCF (SKP1-CUL1-F-box protein) E3 Ubiquitin ligases that mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 is the adapter protein that links Cullin-1 to various F-box proteins (such as SKP2) that serve as the substrate recognition components of SCF ligases. SKP2 targets include proteins involved in cell cycle progression and signal transduction. SKP2 recognizes phosphorylated CDKN1B/ p27Kip and is involved in G1-S cell cycle transition in a CKS1-dependent manner. The Skp1/Skp2 comlex is associated with Cullin-1 (CUL1) a core component of multiple SCF (SKP1-CUL1-F-box) E3 Ubiquitin ligase complexes mediating the ubiquitination of proteins. This complex consists of an N-terminal 6x-His tagged Skp2 and an untagged Skp1. The complex has been expressed and purified from insect cells Sf9.