Catalog number: SBB-CE0021, 100 μg
UBE2D1 is an E2 conjugating enzyme which catalyzes the E3 mediated ubiquitination of a target substrate. It is known to interact with Parkin, and is involved in PINK1 mediated mitophagy. This protein is recombinantly expressed in E.coli. [1][2]
UBE2D1, human recombinant
UBE2D1 is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D1 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D1-Ub thioester. UBE2D1 is capable of associating with numerous known E3 ligases which target abnormal proteins for proteasomal degradation through polyubiquitination. UBE2D1 is also known to interact with Parkin, and to be involved in PINK1 mediated mitophagy. This UBE2D1 is recombinantly expressed in E.coli. The purity of this enzyme is > 95% - determined by SDS-PAGE.