E3 Ligases
Catalog number: SBB-CE0055, 50 μg
Parkin (Parkinson juvenile disease protein 2) is a ~52 kDa E3 Ligase enzyme protein, encoded by PARK2 gene. It plays an important role in the ubiquitin-proteasome system and acts as a regulator of protein breakdown. This protein has been recombinantly expressed in insect cells.
Catalog number: SBB-CE0090, 50 μg
UBE3A ligase E3A) is a 101 kDa E3 Ligase enzyme. The protein contains a C4 type zinc-finger and belongs to the HECT-type E3 ligase family with its site cystein located at aa 843. UBE3A is involved in diseases. It is used by the oncoprotein E6 (HPV) to trigger p53 degradation enabling cervical cancer. This protein has been recombinantly expressed in insect cells.
Catalog number: SBB-CE0107, 25 μg
Parkin (Parkinson juvenile disease protein 2) is a ~52 kDa E3 Ligase enzyme protein, encoded by PARK2 gene. It plays an important role in the ubiquitin-proteasome system and acts as a regulator of protein breakdown. This protein has been recombinantly expressed in insect cells.
Catalog No. SBB-SC0116, 25 µg
Cereblon (CRBN) is the substrate recognition component of DCX (DDB1-CUL4-X-box) E3 Ubiquitin ligase complexes that mediates the ubiquitination of numerous target proteins such as ILF2 and MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8.
Catalog No. SBB-SC0118-50, 25-50 µg
SKP1 (S-phase kinase-associated protein 1) is an essential component of SCF (SKP1-CUL1-F-box protein) E3 Ubiquitin ligases that mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.
Catalog number: SBB-SC0140, 25 μg
DDB1 - DNA damage-binding protein 1, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively.